Characteristics of metastasis and survival between male and female breast cancer with different molecular subtypes: A population‐based observational study

Autor: Wentong Fang, Yue Huang, Xu Han, Jinghui Peng, Mingjie Zheng
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Cancer Medicine, Vol 11, Iss 3, Pp 764-777 (2022)
Druh dokumentu: article
ISSN: 2045-7634
DOI: 10.1002/cam4.4469
Popis: Abstract Objective Male breast cancer (BC) is a rare disease, having different clinicopathological features and survival outcomes from female patients. The aim of this research was to, combine with molecular subtypes, analyze the metastatic patterns, and prognosis between male and female patients, and to determine whether the gender was the independent prognostic factor for BC. Methods Data used in this study were acquired from the SEER database from 2010 to 2016. The clinicopathology features and metastatic patterns were compared by the Chi‐square test and Fisher's exact test. Kaplan–Meier method was performed to compare overall survival (OS) and factors correlated with OS were determined by Cox regression models. Competing risk models were used to ascertain factors related to breast cancer‐specific death (BCSD). Results Compared with female BC, the incidence of regional LN (HR 1.849, 95% CI 1.674–2.043, p
Databáze: Directory of Open Access Journals
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