MDS criteria for the diagnosis of progressive supranuclear palsy overemphasize Richardson syndrome

Autor:	Anika Frank, Kevin Peikert, Jennifer Linn, Moritz D. Brandt, Andreas Hermann
Jazyk:	angličtina
Rok vydání:	2020
Předmět:	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Zdroj:	Annals of Clinical and Translational Neurology, Vol 7, Iss 9, Pp 1702-1707 (2020)
Druh dokumentu:	article
ISSN:	2328-9503
DOI:	10.1002/acn3.51065
Popis:	Abstract MDS‐criteria for clinical diagnosis of progressive supranuclear palsy (PSP) were recently published, their usability in a classical clinical setting is yet unknown. We retrospectively applied the new criteria using PSP patients’ case files. Assignment of PSP diagnosis according to the MDS‐criteria was possible in 57/80 cases. The main difference to former specialist classification was a lower phenotype diversity and higher representation of PSP‐RS. Furthermore, we examined those patients’ brain MRIs. While neuroradiologists’ reports were suggestive of PSP only in 11/62, the analysis of a blinded rater revealed pathological midbrain‐to‐pons‐ratio in 40/62 implying this imaging feature is often missed.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/26acf61b45cd462a8bea57834471460d Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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