| Autor: |
Emma Taylor-Salmon, Verity Hill, Lauren M. Paul, Robert T. Koch, Mallery I. Breban, Chrispin Chaguza, Afeez Sodeinde, Joshua L. Warren, Sylvia Bunch, Natalia Cano, Marshall Cone, Sarah Eysoldt, Alezaundra Garcia, Nicadia Gilles, Andrew Hagy, Lea Heberlein, Rayah Jaber, Elizabeth Kassens, Pamela Colarusso, Amanda Davis, Samantha Baudin, Edhelene Rico, Álvaro Mejía-Echeverri, Blake Scott, Danielle Stanek, Rebecca Zimler, Jorge L. Muñoz-Jordán, Gilberto A. Santiago, Laura E. Adams, Gabriela Paz-Bailey, Melanie Spillane, Volha Katebi, Robert Paulino-Ramírez, Sayira Mueses, Armando Peguero, Nelissa Sánchez, Francesca F. Norman, Juan-Carlos Galán, Ralph Huits, Davidson H. Hamer, Chantal B. F. Vogels, Andrea Morrison, Scott F. Michael, Nathan D. Grubaugh |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
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| Zdroj: |
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2041-1723 |
| DOI: |
10.1038/s41467-024-47774-8 |
| Popis: |
Abstract Dengue is the most prevalent mosquito-borne viral disease in humans, and cases are continuing to rise globally. In particular, islands in the Caribbean have experienced more frequent outbreaks, and all four dengue virus (DENV) serotypes have been reported in the region, leading to hyperendemicity and increased rates of severe disease. However, there is significant variability regarding virus surveillance and reporting between islands, making it difficult to obtain an accurate understanding of the epidemiological patterns in the Caribbean. To investigate this, we used travel surveillance and genomic epidemiology to reconstruct outbreak dynamics, DENV serotype turnover, and patterns of spread within the region from 2009-2022. We uncovered two recent DENV-3 introductions from Asia, one of which resulted in a large outbreak in Cuba, which was previously under-reported. We also show that while outbreaks can be synchronized between islands, they are often caused by different serotypes. Our study highlights the importance of surveillance of infected travelers to provide a snapshot of local introductions and transmission in areas with limited local surveillance and suggests that the recent DENV-3 introductions may pose a major public health threat in the region. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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