Anthocyanin-enriched bilberry extract attenuates glycaemic response in overweight volunteers without changes in insulin

Autor: Mahasin Alnajjar, Sisir Kumar Barik, Charles Bestwick, Fiona Campbell, Morven Cruickshank, Freda Farquharson, Grietje Holtrop, Graham Horgan, Petra Louis, Kim-Marie Moar, Wendy R Russell, Lorraine Scobbie, Nigel Hoggard
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Journal of Functional Foods, Vol 64, Iss , Pp 103597- (2020)
Druh dokumentu: article
ISSN: 1756-4646
DOI: 10.1016/j.jff.2019.103597
Popis: This study investigated the effect of a three week supplementation of bilberry extract on glucose metabolism. Overweight volunteers (n = 16; BMI 31) were given three capsules of either 0.47 g bilberry extract (36% (w/w) anthocyanins) or placebo per day for three weeks in a double blinded cross over intervention.The ingestion of the bilberry extract decreased the OGTT AUCi for glucose (20%; p = 0.008) but not for insulin compared with the placebo. There was no change in anti-inflammatory markers (hsCRP, MCP-1, leptin), vascular health markers (Apo A1, sVCAM-1, sICAM-1), reducing potential/ radical scavenging capacity or faecal bacterial microbiota. In vitro studies showed that the bilberry extract decreased α-amylase activity (p
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