The Shine-Dalgarno sequence of riboswitch-regulated single mRNAs shows ligand-dependent accessibility bursts

Autor: Arlie J. Rinaldi, Paul E. Lund, Mario R. Blanco, Nils G. Walter
Jazyk: angličtina
Rok vydání: 2016
Předmět:
Zdroj: Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/ncomms9976
Popis: In response to intracellular signals, bacterial translational riboswitches embedded in mRNAs can regulate gene expression through inhibition of translation initiation. Here, the authors describe SiM-KARTS, a novel approach for detecting changes in the structure of single RNA molecules in response to a ligand.
Databáze: Directory of Open Access Journals