Effects of Appendectomy on the Onset and Course of Ulcerative Colitis in Chinese Patients

Autor: Dafan Chen, Jing Ma, Shengzheng Luo, Lungen Lu, Xinjian Wan, Qiwen Ben
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Zdroj: Gastroenterology Research and Practice, Vol 2018 (2018)
Druh dokumentu: article
ISSN: 1687-6121
1687-630X
DOI: 10.1155/2018/2927891
Popis: Background. Previous epidemiological studies have suggested that appendectomy may be a protective factor against the development of ulcerative colitis (UC). However, the results of these studies were inconsistent, with rare studies in Chinese populations. Aim. This study examined the associations between appendectomy performed before UC diagnosis and the occurrence and clinical course of UC in Chinese patients. Methods. A case control study was conducted to compare the rate of appendectomy between UC patients and controls matched for age and sex at two Chinese hospitals. Clinical course of UC was compared between UC patients who underwent appendectomies before UC diagnosis and who did not. Results. 402 UC patients and 402 controls were included. The percentage of appendectomy performed before UC diagnosis in UC patients did not differ significantly from controls (2.74% vs 3.98%, P=0.442). Subgroup analysis on the basis of localization of UC patients did not find significant difference from controls. The extent of disease involvement in UC patients who underwent appendectomy was smaller than patients who did not (P=0.009). Appendectomy was found to be significantly related to the location of the disease independent of smoking status in multivariate analysis (P
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