Exploration of Immune Tolerance and Treatment for Esophageal Cancer

Autor: XING Siyuan, FAN Qingxia, SHAN Zhengzheng, MENG Xiangrui, WANG Feng
Jazyk: čínština
Rok vydání: 2023
Předmět:
Zdroj: Zhongliu Fangzhi Yanjiu, Vol 50, Iss 12, Pp 1174-1179 (2023)
Druh dokumentu: article
ISSN: 1000-8578
DOI: 10.3971/j.issn.1000-8578.2023.23.0790
Popis: Monoclonal antibody drugs that inhibit programmed death 1 (PD-1) or programmed death ligand 1 (PD-L1) have been widely used in esophageal cancer (EC) and yielded significant therapeutic responses. However, only a few patients obtain lasting clinical benefits due to primary or acquired drug resistance, and new treatment schemes are urgently needed. The tumor immune microenvironment is the main factor that affects patients' response to immunosuppressive agents. This article will discuss the role of immunosuppressive cells and non-cellular components in the immune process to provide ideas for the next research direction of EC.
Databáze: Directory of Open Access Journals