Antimalarial peroxides: the first intramolecular 1,2,4,5-tetraoxane
| Autor: | BOGDAN A. SOLAJA, WILBUR K. MILHOUS, GABRIELLA POCSFALVI, DEJAN OPSENICA |
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| Jazyk: | angličtina |
| Rok vydání: | 2002 |
| Předmět: | |
| Zdroj: | Journal of the Serbian Chemical Society, Vol 67, Iss 7, Pp 465-471 (2002) |
| Druh dokumentu: | article |
| ISSN: | 0352-5139 |
| Popis: | An intramolecular steroidal 1,2,4,5-tetraoxane has been synthesised in six steps starting from methyl 3-oxo-7a,12a-diacetoxy-5b-cholan-24-oate. The synthesised 1,2,4,5-tetraoxane has moderate in vitro antimalarial activity against P. falciparum strains (IC50 (D6) = 0.35 mg/mL; IC50 (W2) = 0.29 mg/mL). |
| Databáze: | Directory of Open Access Journals |
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