| Autor: |
Z. X. Cui, S. Shen, J. H. Wu, J. H. Si, Q. T. Wang, L-S. Turng, W. Z. Chen |
| Jazyk: |
angličtina |
| Rok vydání: |
2020 |
| Předmět: |
|
| Zdroj: |
eXPRESS Polymer Letters, Vol 14, Iss 9, Pp 794-807 (2020) |
| Druh dokumentu: |
article |
| ISSN: |
1788-618X |
| DOI: |
10.3144/expresspolymlett.2020.66 |
| Popis: |
In this work, the polydopamine (PDA) coating layer was first applied to modify hydroxyapatite (HA) nanoparticles and then the functional PDA/HA (pHA) composite nanoparticles were obtained. Subsequently, a 3-D porous thermoplastic polyurethane (TPU) scaffold modified by two-stage pHA nanoparticles ( pHA-TPU/pHA ) was fabricated by vacuum-assisted solvent casting and ultrasonication-assisted methods. The results demonstrated that the pHA nano-particles were successfully prepared and introduced into the pHA-TPU/pHA composite scaffold both internally and externally. The pHA-TPU/pHA composite scaffold had an excellent interconnected network structure with high porosity of 85.7% and large pore sizes ranging from 100–500 µm. The hydrophilicity and comprehensive mechanical properties of the pHA-TPU/pHA composite scaffold were significantly higher than those of the TPU scaffold due to the addition of the pHA nanoparticles. The attachment and viability of mouse embryonic osteoblast cells (MC3T3-E1) cultured on the pHA-TPU/pHA composite scaffold were also higher than those on the TPU scaffold. These results suggest that the functional pHA-TPU/pHA composite scaffold has superior mechanical and biological properties, which makes it potentially useful for tissue engineering scaffolds. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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