The influenza virus PB2 protein evades antiviral innate immunity by inhibiting JAK1/STAT signalling

Autor: Hui Yang, Yurui Dong, Ying Bian, Nuo Xu, Yuwei Wu, Fan Yang, Yinping Du, Tao Qin, Sujuan Chen, Daxin Peng, Xiufan Liu
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-022-33909-2
Popis: The PB2 subunit of the RNA polymerase of influenza virus antagonizes interferon signalling. Here, the authors biochemically characterise the molecular interactions that mediate this, and how this impacts viral replication in the context of different influenza subtypes.
Databáze: Directory of Open Access Journals