Proteomic response to acupuncture treatment in spontaneously hypertensive rats.

Autor: Xinsheng Lai, Jiayou Wang, Neel R Nabar, Sanqiang Pan, Chunzhi Tang, Yong Huang, Mufeng Hao, Zhonghua Yang, Chunmei Ma, Jin Zhang, Helen Chew, Zhenquan He, Junjun Yang, Baogui Su, Jian Zhang, Jun Liang, Kevin B Sneed, Shu-Feng Zhou
Jazyk: angličtina
Rok vydání: 2012
Předmět:
Zdroj: PLoS ONE, Vol 7, Iss 9, p e44216 (2012)
Druh dokumentu: article
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0044216
Popis: Previous animal and clinical studies have shown that acupuncture is an effective alternative treatment in the management of hypertension, but the mechanism is unclear. This study investigated the proteomic response in the nervous system to treatment at the Taichong (LR3) acupoint in spontaneously hypertensive rats (SHRs). Unanesthetized rats were subject to 5-min daily acupuncture treatment for 7 days. Blood pressure was monitored over 7 days. After euthanasia on the 7(th) day, rat medullas were dissected, homogenized, and subject to 2D gel electrophoresis and MALDI-TOF analysis. The results indicate that blood pressure stabilized after the 5th day of acupuncture, and compared with non-acupoint treatment, Taichong-acupunctured rat's systolic pressure was reduced significantly (P
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