Levels of retinol and retinoic acid in pancreatic cancer, type-2 diabetes and chronic pancreatitis
| Autor: | Pavel Hrabak, Miroslava Zelenkova, Tomas Krechler, Jan Soupal, Michal Vocka, Tomas Hanus, Lubos Petruzelka, Stepan Svacina, Ales Zak, Tomas Zima, Marta Kalousova |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2024 |
| Předmět: | |
| Zdroj: | Biomedical Papers, Vol 168, Iss 2, Pp 132-138 (2024) |
| Druh dokumentu: | article |
| ISSN: | 1213-8118 1804-7521 |
| DOI: | 10.5507/bp.2023.049 |
| Popis: | Aims. Retinoids participate in multiple key processes in the human body e.g., vision, cell differentiation and embryonic development. There is growing evidence of the relationship between retinol, its active metabolite- all-trans retinoic acid (ATRA) - and several pancreatic disorders. Although low levels of ATRA in pancreatic ductal adenocarcinoma (PDAC) tissue have been reported, data on serum levels of ATRA in PDAC is still limited. The aim of our work was to determine serum concentrations of retinol and ATRA in patients with PDAC, type-2 diabetes mellitus (T2DM), chronic pancreatitis (CHP) and healthy controls. Methods. High performance liquid chromatography with UV detection (HPLC) was used to measure serum levels of retinol and ATRA in 246 patients with different stages of PDAC, T2DM, CHP and healthy controls. Results. We found a significant decrease in the retinol concentration in PDAC (0.44+/-0.18 mg/L) compared to T2DM (0.65+/-0.19 mg/L, P |
| Databáze: | Directory of Open Access Journals |
| Externí odkaz: |
|