IL-18 Serum Levels in Patients with Obesity, Prediabetes and Newly Diagnosed Type 2 Diabetes

Autor: Iveta Nedeva, Antoaneta Gateva, Yavor Assyov, Vera Karamfilova, Julieta Hristova, Kyosuke Yamanishi, Zdravko Kamenov, Haruki Okamura
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Iranian Journal of Immunology, Vol 19, Iss 2, Pp 199-206 (2022)
Druh dokumentu: article
ISSN: 1735-1383
1735-367X
DOI: 10.22034/iji.2022.90095.1987
Popis: Background: Obesity and diabetes are related to a chronic low-grade inflammation. As a pro-inflammatory cytokine, IL-18 stimulates various cell types and has pleiotropic functions. Objective: To assess the levels of IL-18 in subjects from the entire spectrum of glycemic disorders. Methods: This study included 387 Caucasians divided into four groups: healthy controls, obese subjects without carbohydrate issues, prediabetic patients, and recently discovered type 2 diabetics. Results: Subject with body mass index ≥30kg/m2 and glycemic disorders showed significantly higher levels of IL-18 (249.77 ± 89.96 pg/ml; 259.01 ± 95.70 pg/ml; and 340.98 ± 127.65 pg/ml) compared with that of the control group (219.47 ± 110.53 pg/ml, p < 0.05). IL-18 also had significant positive associations with some anthropometric parameters, liver enzymes, fasting, post-load glucose, insulin, uric acid, and triglycerides while negative with HDL. The circulating IL-18 levels for differentiating subjects with carbohydrate disturbances and those with metabolic syndrome were determined by ROC analysis. The AUC for the disturbances of the carbohydrate metabolism was 0.597 (p = 0.001; 95% CI = 0.539 - 0.654) and for MS AUC was 0.581 (p = 0.021; 95 % CI = 0.516 - 0.647). Conclusion: Our data indicate that as the levels of IL-18 are increased the carbohydrate tolerance is deteriorated. However, the significance of IL-18 in the progression of diabetes mellitus and subsequent consequences requires further exploration.
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