| Autor: |
Marta Stasiak, Joanna Boncela, Corinne Perreau, Konstantina Karamanou, Aurore Chatron-Colliet, Isabelle Proult, Patrycja Przygodzka, Shukti Chakravarti, François-Xavier Maquart, M Anna Kowalska, Yanusz Wegrowski, Stéphane Brézillon |
| Jazyk: |
angličtina |
| Rok vydání: |
2016 |
| Předmět: |
|
| Zdroj: |
PLoS ONE, Vol 11, Iss 3, p e0150226 (2016) |
| Druh dokumentu: |
article |
| ISSN: |
1932-6203 |
| DOI: |
10.1371/journal.pone.0150226 |
| Popis: |
Lumican, a small leucine rich proteoglycan, inhibits MMP-14 activity and melanoma cell migration in vitro and in vivo. Snail triggers epithelial-mesenchymal transitions endowing epithelial cells with migratory and invasive properties during tumor progression. The aim of this work was to investigate lumican effects on MMP-14 activity and migration of Snail overexpressing B16F1 (Snail-B16F1) melanoma cells and HT-29 colon adenocarcinoma cells. Lumican inhibits the Snail induced MMP-14 activity in B16F1 but not in HT-29 cells. In Snail-B16F1 cells, lumican inhibits migration, growth, and melanoma primary tumor development. A lumican-based strategy targeting Snail-induced MMP-14 activity might be useful for melanoma treatment. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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