Human Adipose-Derived Stem Cells Promote Seawater-Immersed Wound Healing by Activating Skin Stem Cells via the EGFR/MEK/ERK Pathway
Autor: | Jiachao Xiong, Boyao Ji, Liujun Wang, Yazhou Yan, Zhixiao Liu, Shuo Fang, Minjuan Wu, Yue Wang, Jianxing Song |
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Jazyk: | angličtina |
Rok vydání: | 2019 |
Předmět: | |
Zdroj: | Stem Cells International, Vol 2019 (2019) |
Druh dokumentu: | article |
ISSN: | 1687-966X 1687-9678 77749766 |
DOI: | 10.1155/2019/7135974 |
Popis: | Seawater (SW) immersion can increase the damage of skin wounds and produce refractory wounds. However, few studies have been conducted to investigate the mechanisms of SW immersion on skin wounds. In our current study, we investigated the effect of human adipose-derived stem cells (hADSCs) on the repair of SW-treated full-thickness skin wounds and the underlying mechanisms. The results showed that SW immersion could reduce the expression of EGF and suppress the activation of the MEK/ERK signaling pathway. At the same time, the proliferation and migration of skin stem cells were inhibited by SW immersion, resulting in delayed wound healing. However, hADSCs significantly accelerated the healing of SW-immersed skin wounds by promoting cell proliferation and migration through the aforementioned mechanisms. Our results indicate a role for hADSCs in the repair of seawater-immersed skin wounds and suggest a potential novel treatment strategy for seawater-immersed wound healing. |
Databáze: | Directory of Open Access Journals |
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