| Autor: |
Maria Naumenko, Petr Snetkov, Tatiana Gribinichenko, Anna Bervinova, Svetlana Morozkina, Sergei Zhuravskii |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
|
| Zdroj: |
Engineering Proceedings, Vol 56, Iss 1, p 32 (2023) |
| Druh dokumentu: |
article |
| ISSN: |
2673-4591 |
| DOI: |
10.3390/ASEC2023-15260 |
| Popis: |
Septal cartilage defects and tympanic membrane perforations are some of the main challenging clinical problems in modern ENT (Ear, Nose and Throat) surgery. Polymer films based on biocompatible and biodegradable polymers seem to represent prospective materials for surgical reconstruction of such defects. In this study, we present the results of pilot in vivo experiments of the biocompatibility and biodegradability of bilayer films obtained via the casting method from hyaluronic acid (MW = 1300 kDa) and chitosan (500 and 900 kDa) polymer solutions. The total toxicity, pro-inflammatory activity, biodegradation rate and proliferative potential of the connective tissue of the dermis in the implantation area were evaluated on days 7, 14, 30 and 50 after the implantation. The studied samples demonstrated negligible overall acute and chronic toxicity. The influence of the preparation technique as well as the effect of chitosan’s MW on the biodegradation rate are also demonstrated. These bilayer polymer films can be recommended for ENT surgery, in particular for the reconstruction of the nasal septum and tympanic membrane. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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