| Autor: |
Ben-Cherif Wafa, Dridi Ichrak, Aouam Karim, Ben-Attia Mossadok, Reinberg Alain, Boughattas Naceur A |
| Jazyk: |
angličtina |
| Rok vydání: |
2012 |
| Předmět: |
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| Zdroj: |
Journal of Circadian Rhythms, Vol 10, Iss 1, p 3 (2012) |
| Druh dokumentu: |
article |
| ISSN: |
1740-3391 |
| DOI: |
10.1186/1740-3391-10-3 |
| Popis: |
Abstract Background Valproic acid (VPA) is an antiepileptic drug widely used for the treatment of absence seizures and generalized tonic-clonic seizures. The present work aims to study whether VPA-induced toxicity varies according to the dosing-time in the 24 hour-scale. Methods The influence of dosing-time on tolerance to VPA was investigated in 120 male Swiss mice synchronized under a light-dark cycle (12:12). The mean VPA lethal dose was first determined to be 850 ± 0.2 mg/kg, i.p.. Such a dose was administered by i.p. route to a total of 90 mice divided in six circadian stages [1, 5, 9, 13, 17 and 21 Hours After Light Onset (HALO)] (15 mice/circadian time); 30 mice were used as control (5 mice / circadian time). Results The surviving treated mice exhibited a significant circadian variation in rectal temperature and body weight loss (p 2 = 42.1, p Conclusions With regards to these data the optimal tolerance to VPA occurred when the drug was administered in the second half of the light-rest span of mice which is physiologically analogous to the second half of the night for human patients. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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