| Autor: |
Masome Rashno, Seyed Reza Fatemi Tabatabaei, Mahmood Khaksary Mahabady, Shahab Ghaderi |
| Jazyk: |
angličtina |
| Rok vydání: |
2014 |
| Předmět: |
|
| Zdroj: |
Anatomical Sciences Journal, Vol 11, Iss 1, Pp 41-52 (2014) |
| Druh dokumentu: |
article |
| ISSN: |
2322-3626 |
| Popis: |
Introduction: - Significant increase in usage of silver nanoparticles (AgNPs) in consumer products, has increased its exposures to human and animals. Although there are some reports regarding the effects of AgNPs on complex organisms, no report was found as to its effects on neurobehavioral ontogeny. Methods: To investigate the effects of maternal exposure to AgNPs on development of neurobehavioral reflexes as well as physical indexes of growthand development during preweaning period, virgin female NMRI mice were treated with zero, 5 and 50 μg/mouse AgNPs. AgNPs were injected subcutaneously (S.C) to female mice, immediately following male exposure and at once every three days until parturition. Reproductive performance of dams were assessed and home cage activity and developmental landmarks of all pups were observed daily. Gross necropsy was performed on the 28th day. Results: No significant differences were observed in dams' and pups' weight. Survival rate was decreased (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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