Neighborhood Socioeconomic Status and Cardiovascular Events in Adults With CKD: The CRIC Study

Autor: Avi G. Aronov, Milda R. Saunders, Jesse Y. Hsu, Daohang Sha, Martha Daviglus, Michael J. Fischer, Lawrence J. Appel, James Sondheimer, Jiang He, Hernan Rincon-Choles, Edward J. Horwitz, Tanika N. Kelly, Ana C. Ricardo, James P. Lash, Jing Chen, Debbie L. Cohen, Laura M. Dember, Amada H. Anderson, Alan S. Go, Robert G. Nelson, Mahboob Rahman, Panduranga S. Rao, Vallabh O. Shah, Mark L. Unruh
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Kidney Medicine, Vol 6, Iss 11, Pp 100901- (2024)
Druh dokumentu: article
ISSN: 2590-0595
DOI: 10.1016/j.xkme.2024.100901
Popis: Rationale & Objective: In the general population, neighborhood socioeconomic status (SES) has been found to be associated with cardiovascular risk, but this relationship has not been well studied among patients with chronic kidney disease (CKD). This study seeked to evaluate the association between neighborhood SES and cardiovascular outcomes in a CKD cohort. Study Design: Multicenter prospective cohort. Setting & Participants: In total, 3,197 participants in the Chronic Renal Insufficiency Cohort Study without cardiovascular disease at baseline. Exposure: Neighborhood SES quartiles using a validated neighborhood-level SES summary measure for 6 census-derived variables. Outcome: Incident heart failure, myocardial infarction, and all-cause death. Analytical Approach: Cox proportional hazards. Results: During median follow-up of 8.8 years, there were 465 incident heart failure events, 297 myocardial infarctions, and 891 deaths. In a fully adjusted model, among individuals with estimated glomerular filtration rate ≥45 mL/min/1.73 m2, lowest neighborhood SES quartile was associated with higher risk of heart failure (HR, 1.96 [95% CI, 1.04-3.67]) compared with the highest quartile. This association was not significant among those with estimated glomerular filtration rate
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