Impact of baseline renal function on the efficacy and safety of different Anticoagulants in Atrial Fibrillation Patients – A cohort study

Autor:	Wei-Chieh Lee, Ting-Wei Liao, Hsiu-Yu Fang, Po-Jui Wu, Yen-Nan Fang, Huang-Chung Chen, Yu-Sheng Lin, Shang-Hung Chang, Ping-Yen Liu, Mien-Cheng Chen
Jazyk:	angličtina
Rok vydání:	2022
Předmět:	Atrial fibrillation Direct oral anticoagulant Renal impairment Vitamin K antagonists Safety Diseases of the blood and blood-forming organs RC633-647.5
Zdroj:	Thrombosis Journal, Vol 20, Iss 1, Pp 1-8 (2022)
Druh dokumentu:	article
ISSN:	1477-9560
DOI:	10.1186/s12959-022-00423-w
Popis:	Abstract Background Vitamin K antagonists and different direct oral anticoagulants (DOACs) have different renal clearance rates. However, the impact of different stages of chronic renal impairment on the efficacy and safety of warfarin, dabigatran, rivaroxaban, apixaban, and edoxaban in atrial fibrillation (AF) patients remains unclear. Methods This study enrolled AF patients from the Chang Gung Research Database. The study endpoints included thromboembolic events, major/fatal bleeding, gastrointestinal (GI) bleeding and intracranial hemorrhage (ICH). The risks of time to study endpoints between groups were compared using a Cox proportional hazards regression model with adjustment. Results This study enrolled 3525 patients with moderate renal impairment (30 ≤ creatinine clearance (CrCl)
Databáze:	Directory of Open Access Journals
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