EXPERIMENTAL AND CLINICAL EPILEPTOLOGY
| Autor: | G. N. Avakyan, O. L. Badalyan, S. G. Burd, Е. А. Valdman, Т. А. Voronina, L. N. Nerobkova, Е. V. Krikova, G. G. Аvakyan, A. S. Chukanova, M. I. Stoyko, А. А. Savenkov |
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| Jazyk: | ruština |
| Rok vydání: | 2016 |
| Předmět: | |
| Zdroj: | Эпилепсия и пароксизмальные состояния, Vol 2, Iss 4, Pp 41-54 (2016) |
| Druh dokumentu: | article |
| ISSN: | 2077-8333 2311-4088 |
| Popis: | This article reviews the issues of experimental and clinical epileptology. For the development and implementation of new medications and technologies of medicinal interventions, as well as investigation of main “targets” for anti-epileptic drugs, it is necessary to develop the experimental models of various forms of epilepsy and epileptic seizures. To this end, we studied the alterations of cerebral electrical activity in rats with chronic cobalt epileptogenic focus which represents an optimal experimental model of epileptic state. The significance of hypothalamus was shown to be the lead (determinate) structure within the pathologic epileptic system during formation of secondary generalized seizures. The drug” targets” and possibilities for combined administration of anticonvulsants and antioxidants have been revealed. Pharmaco-genetic investigations enable us to predict the effects of different antiepileptic drugs. |
| Databáze: | Directory of Open Access Journals |
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