Improving infant Neurocognitive Development and Growth Outcomes with micronutrients (INDiGO): A protocol for an efficacy trial in rural Gambia [version 1; peer review: 2 approved]

Autor: Samantha McCann, Sophie E. Moore, Muhammed A. Danjo, Ousman Jarjou, Samuel Beaton, Bakary Sonko, Greg Fegan, Daniel Tod, Andrew M. Prentice, Ebrima Sise
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Wellcome Open Research, Vol 9 (2024)
Druh dokumentu: article
ISSN: 2398-502X
DOI: 10.12688/wellcomeopenres.21282.1
Popis: Background Undernutrition during the early years of life has a harmful and irreversible impact on child growth and cognitive development. Many of the interventions tested to improve outcomes across infancy have had disappointing or inconsistent impact, a common feature being the absence of any attempt to provide nutritional supplements to infants during the first six months. With increasing evidence of micronutrient deficiencies in this age group, alongside strong evidence that growth and developmental deficits begin before six months, a renewed focus on the micronutrient status of infants is required. Methods This study is a five-arm, double-blind, placebo-controlled, randomised efficacy trial of micronutrient supplementation to mothers (during pregnancy or pregnancy and lactation) and infants (Day 8 to six months of age) in rural Gambia, where rates of micronutrient deficiencies are high. 600 pregnant women (
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