| Autor: |
Mohammad Faheem Khan, Arun Kumar Rawat, Shahnaaz Khatoon, Mohd Kamil Hussain, Arvind Mishra, Devendra Singh Negi |
| Jazyk: |
angličtina |
| Rok vydání: |
2018 |
| Předmět: |
|
| Zdroj: |
Integrative Medicine Research, Vol 7, Iss 2, Pp 176-183 (2018) |
| Druh dokumentu: |
article |
| ISSN: |
2213-4220 |
| DOI: |
10.1016/j.imr.2018.03.004 |
| Popis: |
Background: To investigate the antidiabetic effect of Himalayan Medicinal plants from India viz. Melia azedarach (Family: Meliaceae), Zanthoxylum alatum (Family: Rutaceae), Tanacetum nubigenum (Family: Asteraceae) using in-vitro as well as in-vivo approaches. Methods: Their effects were examined on stimulation of glucose uptake by C2C12 cultured cell line, inhibitory effect on human recombinant Protein tyrosine phosphatase-1B (PTP-1B) and followed by the hypoglycaemic activity of extracts in Streptozotocin (STZ) induced diabetic rats. Results: All prepared extracts had been found to enrich with polyphenolic, flavonoids, terpenoids, anthraquinones and saponins type of compounds. n-Butanol fraction of Zanthoxylum alatum showed maximum PTP-1B inhibition (61.9%) whereas ethanol extract of Tanacetum nubigenum showed strong stimulation of glucose uptake (+61.2%) in C2Cl2 myotubes. In STZ induced Sprague-Dawley rats, significant decrease in blood glucose level was observed in ethanol extract of Melia azaderach treated group as 14.8% (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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