Genetic prediction of the relationship between metabolic syndrome and colorectal cancer risk: a Mendelian randomization study

Autor: Chendong Yuan, Xufeng Shu, Zhenzhen Hu, Zhigang Jie
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Diabetology & Metabolic Syndrome, Vol 16, Iss 1, Pp 1-12 (2024)
Druh dokumentu: article
ISSN: 1758-5996
DOI: 10.1186/s13098-024-01351-7
Popis: Abstract Background Despite a growing body of observational studies indicating a potential link between metabolic syndrome and colorectal cancer, a definitive causal relationship has yet to be established. This study aimed to elucidate the causal relationship between metabolic syndrome and colorectal cancer through Mendelian randomization. Methods We screened for instrumental variables associated with metabolic syndrome and its diagnostic components and with colorectal cancer through the use of a genome-wide association study database, and conducted a preliminary Mendelian randomization analysis. To corroborate the dependability of our conclusions, an additional dataset was used for replication analysis in a Mendelian randomization method, which was further integrated with a meta-analysis. Results Preliminary analysis using the inverse variance weighted method revealed positive correlations between metabolic syndrome (OR [95% CI] = 1.37[1.15–1.63], P = 5.02 × 10–4) and waist circumference (OR [95% CI] = 1.39[1.21–1.61], P = 7.38 × 10–6) and the risk of colorectal cancer. Replication analysis also revealed the same results: metabolic syndrome (OR [95% CI] = 1.24[1.02–1.51], P = 0.030) and waist circumference (OR [95% CI] = 1.23[1.05–1.45], P = 0.013). The meta-analysis results further confirmed the associations between metabolic syndrome (OR [95% CI] = 1.31[1.15–1.49], P
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