Idiopathic hypereosinophilic syndrome presenting with recalcitrant oral and genital ulcers responding well to thalidomide

Autor: Sahana M Srinivas, Pooja G Chebbi, Sanjay K Shivappa
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Indian Dermatology Online Journal, Vol 14, Iss 5, Pp 676-678 (2023)
Druh dokumentu: article
ISSN: 2229-5178
DOI: 10.4103/idoj.idoj_632_22
Popis: Hypereosinophilic syndrome is a myeloproliferative disorder characterized by abnormal accumulation of eosinophils in the blood or peripheral tissues. It is uncommonly seen in children. We describe a 14-year-old girl diagnosed with idiopathic hypereosinophilic syndrome presenting with recurrent, painful oral and genital ulcers, hepatosplenomegaly along with consistently high eosinophil count and leucocytosis. Genetic studies showed negative for FIPIL-PDGFRA fusion gene. Mucosal ulcers were recalcitrant to conventional therapy and responded well to thalidomide.
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