| Autor: |
Lotfali Lotfi, Bahman Mirzaei, Javad Mehrabani |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
|
| Zdroj: |
Journal of Exercise & Organ Cross Talk, Vol 4, Iss 2, Pp 86-98 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2783-2074 |
| DOI: |
10.22122/jeoct.2024.475229.1120 |
| Popis: |
The aim of this study was the effect of endurance exercise and probiotic supplement enriched with amino acid leucine and vitamin D on the gut-muscle axis in aged male rats. For this purpose, 25 male Wistar rats (5 rats in each group) in two age groups of 8 to 12 weeks (young) and 18 to 24 months (elderly) were randomly divided into 5 equal groups of old control (OC), young control (YC), endurance exercise (OE), supplement group (OS) and endurance exercise plus supplement (OES) were divided. The results showed that 8 weeks of endurance training (three times a week) and supplemental oral gavage (5 times a week) caused a significant change in postbiotics (decrease of indoxyl sulfate (IXS) and increase of Short-chain fatty acids (SCFAs)). The role of OS in reducing IXS was more prominent than OE and OES variables; of course, the synergistic effect of OES (P=0.000), caused a greater improvement in the amount of SCFA. Also, Administering the supplement alone and at rest (without exercise) could not cause a significant increase in VO2max (P=0.449). But, the effect of exercise on increasing VO2max index was more effective than OS and even OES. Eventually, the independent variables made a significant difference on the Villus height (VH) (except for the OS group) and number of goblet cells (GC) compared to the OC group (P |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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