| Autor: |
Flavia Rezende, Christoph Schürmann, Susanne Schütz, Sabine Harenkamp, Eva Herrmann, Michael Seimetz, Norbert Weißmann, Katrin Schröder |
| Jazyk: |
angličtina |
| Rok vydání: |
2017 |
| Předmět: |
|
| Zdroj: |
Redox Biology, Vol 11, Iss , Pp 312-314 (2017) |
| Druh dokumentu: |
article |
| ISSN: |
2213-2317 |
| DOI: |
10.1016/j.redox.2016.12.012 |
| Popis: |
The free radical theory of aging suggests reactive oxygen species as a main reason for accumulation of damage events eventually leading to aging. Nox4, a member of the family of NADPH oxidases constitutively produces ROS and therefore has the potential to be a main driver of aging. Herein we analyzed the life span of Nox4 deficient mice and found no difference when compared to their wildtype littermates. Accordingly neither Tert expression nor telomere length was different in cells isolated from those animals. In fact, Nox4 mRNA expression in lungs of wildtype mice dropped with age. We conclude that Nox4 has no influence on lifespan of healthy mice. Keywords: Nox4, Aging |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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