| Autor: |
X. Cubiró, C. Garcia-Melendo, C.E. Morales-Munera, A. Riera-Mestre, R. Torres-Iglesias, B. Villanueva, L. Puig, E. Baselga |
| Jazyk: |
English<br />Spanish; Castilian |
| Rok vydání: |
2024 |
| Předmět: |
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| Zdroj: |
Actas Dermo-Sifiliográficas, Vol 115, Iss 3, Pp 246-257 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
0001-7310 |
| DOI: |
10.1016/j.ad.2023.10.017 |
| Popis: |
Background: Hereditary haemorrhagic telangiectasia (HHT) is characterized by the presence of telangiectases and larger arteriovenous malformations in different organs. Mucocutaneous telangiectases can bleed and become an aesthetic concern, impairing quality of life (QoL). However, the best treatment approach has not been defined yet. Objective: To evaluate the efficacy and safety of dual wavelength sequential 595/1064 nm laser (DWSL) compared to 1064 nm laser (Nd:YAG) alone. Secondarily, to evaluate QoL impairment in HHT patients, and its improvement with laser therapy. Methods: A comparative randomized split-body double-blinded prospective study (DWSL vs Nd:YAG). Demographic, clinical and treatment characteristics were recorded. The severity and degree of improvement were evaluated by three blinded examiners who scored pre-treatment and post-treatment pictures on a 5-point scale. Patients fulfilled Skindex-29 and FACE-Q® tests and assessed procedure-associated pain and patient satisfaction. Results: 111 treatment areas (55 treated with DWSL and 56 with Nd:YAG) from 26 patients were analyzed. The median number of laser sessions was 2 (interquartile range [IQR] 2–4; mean 2.90 vs 2.88, respectively). The median improvement score, irrespective of location, was significantly higher for Nd:YAG compared to DWSL: 3 (IQR 2–3; mean 2.61) vs 2 (IQR 2–3; mean 2.32), p = 0.031. Both FACE-Q index and Skindex-29 test results improved significantly (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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Full Text from ScienceDirect