3D-printed biodegradable polycaprolactone rib implants with tissue-specific mechanical properties promote chest wall recovery by stimulating tissue fibrosis
| Autor: | Zijie Meng, Shangyuan Yang, Feiyang Yin, Xiao Liang, Xiaolong Yan, Xinyu Li, Jiankang He, Lei Wang, Dichen Li |
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| Jazyk: | angličtina |
| Rok vydání: | 2024 |
| Předmět: | |
| Zdroj: | Virtual and Physical Prototyping, Vol 19, Iss 1 (2024) |
| Druh dokumentu: | article |
| ISSN: | 17452759 1745-2767 1745-2759 |
| DOI: | 10.1080/17452759.2024.2346816 |
| Popis: | ABSTRACTHere we developed a tripartite biodegradable rib implant with tissue-specific mechanical properties by employing polycaprolactone and a dual-structure-reinforced selective laser sintering (SLS) strategy. Computational simulation revealed that the tripartite rib implant, with a 9 mm diameter load-bearing structure, exhibited a rib-like three-point bending stiffness of 31.3 N/mm, can withstand a maximum force of 121.5 N, and restore similar respiration movements of natural ribs. The modified SLS enabled the fabrication of the as-designed rib implants with improved mechanical properties while maintaining structural fidelity compared to conventional SLS, and their mechanical properties were validated through three-point bending, impact, and flexural fatigue testing. The 3D-printed biodegradable tripartite rib implant effectively prevented abnormal breathing and significantly improved the chest wall's morphological and physiological functions in a large-scale canine rib defect model. This exploration provides a promising approach to engineer biodegradable rib implants with tissue-specific mechanical properties for the long-term repair of chest wall defects. |
| Databáze: | Directory of Open Access Journals |
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