| Autor: |
Valentin Hubacher, Manuel Egle, Selianne Graf, Maria Arnold, Adrian Segiser, Maria Nieves Sanz, Daniela Casoni, Luisana Garcia Casalta, Kay Nettelbeck, Maks Mihalj, Matthias Siepe, Alexander Kadner, Sarah Longnus |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
|
| Zdroj: |
Frontiers in Cardiovascular Medicine, Vol 11 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2297-055X |
| DOI: |
10.3389/fcvm.2024.1325160 |
| Popis: |
BackgroundDuring donation after circulatory death (DCD), cardiac grafts are exposed to potentially damaging conditions that can impact their quality and post-transplantation outcomes. In a clinical DCD setting, patients have closed chests in most cases, while many experimental models have used open-chest conditions. We therefore aimed to investigate and characterize differences in open- vs. closed-chest porcine models.MethodsWithdrawal of life-sustaining therapy (WLST) was simulated in anesthetized juvenile male pigs by stopping mechanical ventilation following the administration of a neuromuscular block. Functional warm ischemic time (fWIT) was defined to start when systolic arterial pressure was |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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