Cannabidiol decreases histological intestinal injury in a neonatal experimental model of necrotizing enterocolitis

Autor:	Nerea Huertos Soto, Juan Manuel Gómez Cervantes, María Jesús Fernández Aceñero, María del Carmen Soto Beauregard
Jazyk:	angličtina
Rok vydání:	2024
Předmět:	Enterocolitis Cannabidiol Newborn Intestine Murine experimental model Medicine (General) R5-920 Biology (General) QH301-705.5
Zdroj:	Laboratory Animal Research, Vol 40, Iss 1, Pp 1-11 (2024)
Druh dokumentu:	article
ISSN:	2233-7660
DOI:	10.1186/s42826-024-00211-9
Popis:	Abstract Background Necrotizing enterocolitis (NEC) is a severe inflammatory bowel disease in neonates. Our group has developed an experimental model of NEC, with an effectiveness of 73%. Cannabidiol (CBD) is an innovative treatment for neonatal cerebral hypoxic-ischemic pathologies due to its neuroprotective effect, as a potent anti-inflammatory and reducing oxidative stress substance. Our aim was to evaluate the effect of CBD on intestinal lesions in an experimental model of NEC. Results Mortality and intestinal histological damage was significantly lower in the CBD group compared to the rest (p
Databáze:	Directory of Open Access Journals
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