Different Therapeutic Strategies in 2 Young Patients with Advanced ALK-Rearranged Lung Adenocarcinoma: 'The Light at the End of the Tunnel'

Autor:	Umberto Caterino, Cristiano Cesaro, Enzo Zamparelli, Flavio Cesaro, Alba Palma, Raffaella Lucci, Pasquale Imitazione, Dino Casazza, Dario Amore
Jazyk:	angličtina
Rok vydání:	2021
Předmět:	lung adenocarcinoma malignant pleural effusion anaplastic lymphoma kinase inhibitor therapy Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Zdroj:	Case Reports in Oncology, Vol 14, Iss 3, Pp 1616-1620 (2021)
Druh dokumentu:	article
ISSN:	1662-6575
DOI:	10.1159/000520127
Popis:	Malignant pleural effusion represents a prognostic negative factor on survival conferring stage IV disease. The median of survival is 5 months and a 5-year survival of about 3%. We describe the therapeutic success obtained from different strategies in anaplastic lymphoma kinase (ALK) inhibitors in 2 young women showing malignant pleural effusion secondary to advanced ALK-rearranged lung adenocarcinoma. This report shows that for patients with EGFR mutations in advanced lung adenocarcinoma-associated malignant pleural effusion, complete response to EGFR TKI inhibitor can be observed mostly if pleural effusion and primary lung adenocarcinoma show the same EGFR mutation status.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/a25798b70e3548b9b36e29ee8da2a987 Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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