Autor: |
Ritobrita Chakraborty, Sandip Dey, Pallabi Sil, Simanta Sarani Paul, Dipita Bhattacharyya, Anirban Bhunia, Jayati Sengupta, Krishnananda Chattopadhyay |
Jazyk: |
angličtina |
Rok vydání: |
2021 |
Předmět: |
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Zdroj: |
Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021) |
Druh dokumentu: |
article |
ISSN: |
2399-3642 |
DOI: |
10.1038/s42003-021-02026-z |
Popis: |
Chakraborty et al. present biophysical and structural insights into fibril-forming oligomers of alpha-synuclein stabilized by heme. They show that heme targets the His50 residue of the oligomers and locks the protein into a different conformation which leads to non-toxic, non-fibrillating oligomer formation, therefore addressing a very important issue in the field of structure of transient oligomers. |
Databáze: |
Directory of Open Access Journals |
Externí odkaz: |
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