A concise assessment of salivary modifications in patients with chronic hepatitis

Autor: Daniela-Gabriela BADITA, Dan PIPEREA-SIANU, Andra-Elena BALCANGIU-STROESCU, Bogdan CALENIC, Maria GREABU, Maria-Daniela TANASESCU, Laura RADUCU, Iulia-Ioana STANESCU
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Zdroj: Romanian Journal of Medical Practice, Vol 12, Iss 3, Pp 152-157 (2017)
Druh dokumentu: article
ISSN: 1842-8258
2069-6108
DOI: 10.37897/RJMP.2017.3.5
Popis: Background. Saliva is a complex biological fluid that has great potential as a diagnosis fluid for both oral and systemic diseases. At the same time, chronic hepatitis affects millions of people worldwide and can lead to liver cirrhosis and hepatocellular carcinoma. In this context, our research group aimed to evaluate the modifications produced in the saliva of patients with chronic hepatitis compared to healthy subjects. Material and method. The present work included 88 subjects that were divided into 4 groups, each consisting of 22 people. Saliva samples were collected for each participant to the study. Salivary levels of total protein (TP), IgA, IgG and aminotransferases AST (aspartate aminotransferase) and ALT (alanine amino-transferase) were determined. Results. Our results showed significantly increased salivary levels of TP, IgA, AST and ALT for patients with chronic viral hepatitis (CHV) and chronic alcoholic hepatitis (CAH) compared to controls. IgG salivary levels were also higher in patients with hepatitis versus controls, however while statistical significance could be found for patients with chronic hepatitis C (CHC) and CAH, this was not the case for the patients with chronic hepatitis B (CHB). Conclusions. The results of our study showed significantly increased salivary levels of the determined parameters in hepatitis patients compared to the healthy subjects, hence promoting the use of saliva as a diagnosis and monitoring fluid for chronic hepatitis.
Databáze: Directory of Open Access Journals
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