| Autor: |
N. Malandrino, J. C. Reynolds, R. J. Brychta, K. Y. Chen, S. Auh, A. M. Gharib, M. Startzell, E. K. Cochran, R. J. Brown |
| Jazyk: |
angličtina |
| Rok vydání: |
2019 |
| Předmět: |
|
| Zdroj: |
Obesity Science & Practice, Vol 5, Iss 1, Pp 75-82 (2019) |
| Druh dokumentu: |
article |
| ISSN: |
2055-2238 |
| DOI: |
10.1002/osp4.319 |
| Popis: |
Summary Objectives Lipodystrophies are characterized by regional or generalized loss of adipose tissue and severe metabolic complications. The role of visceral adipose tissue (VAT) in the development of metabolic derangements in lipodystrophy is unknown. The study aim was to investigate VAT contribution to metabolic disease in lipodystrophy versus healthy controls. Methods Analysis of correlations between VAT volume and biomarkers of metabolic disease in 93 patients and 93 age/sex‐matched healthy controls. Results Patients with generalized lipodystrophy (n = 43) had lower VAT compared with matched controls, while those with partial lipodystrophy (n = 50) had higher VAT versus controls. Both groups with lipodystrophy had lower leg fat mass versus controls (p 0.05 for all; Spearman correlation). In controls matched to patients with generalized or partial lipodystrophy, VAT correlated with glucose (R = 0.42 and 0.36), triglycerides (R = 0.36 and 0.60) and high‐density lipoprotein cholesterol (R = −0.34 and −0.64) (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
|
Plný text