Combined dapagliflozin and roxadustat effectively protected heart and kidney against cardiorenal syndrome-induced damage in rodent through activation of cell stress-Nfr2/ARE signalings and stabilizing HIF-1α

Autor:	Pei-Hsun Sung, Ya Yue, Yi-Ling Chen, John Y. Chiang, Ben-Chung Cheng, Chih-Chao Yang, Han-Tan Chai, Hon-Kan Yip
Jazyk:	angličtina
Rok vydání:	2024
Předmět:	Cardiorenal syndrome Dapagliflozin Roxadustat Oxidative stress Hypoxia inducible factor Therapeutics. Pharmacology RM1-950
Zdroj:	Biomedicine & Pharmacotherapy, Vol 180, Iss , Pp 117567- (2024)
Druh dokumentu:	article
ISSN:	0753-3322
DOI:	10.1016/j.biopha.2024.117567
Popis:	Background: This study tested whether combined dapagliflozin (DAPA) and roxadustat (ROX) therapy was superior to a singular therapy in protecting heart and kidney functions in rats with cardiorenal syndrome (CRS). Methods and results: An in vitro study demonstrated that the cell survival (PI3K/Akt/mTOR)/cell stress (ERK1/2, JNK/p-38) signaling was significantly activated by combination therapy with ROX-DAPA (all p
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/2560481bcecf42fcab507489c7caaca8 Zobrazit plný text záznamu Full Text from ScienceDirect View record in DOAJ