Macroautophagy and Cell Responses Related to Mitochondrial Dysfunction, Lipid Metabolism and Unconventional Secretion of Proteins

Autor: Thierry Arnould, Patricia Renard, Anaïs Wanet, Kayleen Vannuvel, Sébastien Michel, Stéphane Demine
Jazyk: angličtina
Rok vydání: 2012
Předmět:
Zdroj: Cells, Vol 1, Iss 2, Pp 168-203 (2012)
Druh dokumentu: article
ISSN: 2073-4409
DOI: 10.3390/cells1020168
Popis: Macroautophagy has important physiological roles and its cytoprotective or detrimental function is compromised in various diseases such as many cancers and metabolic diseases. However, the importance of autophagy for cell responses has also been demonstrated in many other physiological and pathological situations. In this review, we discuss some of the recently discovered mechanisms involved in specific and unspecific autophagy related to mitochondrial dysfunction and organelle degradation, lipid metabolism and lipophagy as well as recent findings and evidence that link autophagy to unconventional protein secretion.
Databáze: Directory of Open Access Journals