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Objective: To assess serum total cholesterol, low density lipoproteincholesterol, high density lipoprotein cholesterol, very low densitylipoprotein cholesterol and triglyceride levels in pregnant womenaged over 35 years during the first and second trimesters ofpregnancy, and to relate theses values with the diagnosis ofpre-eclampsia in the 3rd trimester of pregnancy. Methods: Fiftythreepregnant women were divided into two groups, one withno pre-eclampsia and another diagnosed with pre-eclampsia.Five pregnant women were excluded due to miscarriages. Serumtotal cholesterol, low density lipoprotein cholesterol, high densitylipoprotein cholesterol, very low density lipoprotein cholesteroland triglyceride levels were measured in all pregnant womenduring the first and second trimesters of pregnancy. Results:Thirty-nine pregnant women had no pre-eclampsia and nine werediagnosed with pre-eclampsia. Serum total cholesterol, low densitylipoprotein cholesterol and triglyceride levels were similar inboth groups during the first and second trimesters of pregnancy(p = 0.25, p = 0.71 and p = 0.30, respectively). However,serum total cholesterol, low density lipoprotein cholesterol andtriglyceride levels were significantly higher during the secondtrimester compared to the first trimester in both groups (p < 0.001,p < 0.005 and p < 0.001, respectively). Serum high densitylipoprotein cholesterol and very low density lipoprotein cholesterollevels were similar in both groups during the first trimester(p = 0.21 and p = 0.38, respectively); during the second trimester,however, these levels were significantly higher in the pre-eclampsiagroup compared to the group with no pre-eclampsia (p = 0.005 andp = 0.003, respectively). Furthermore, serum high density lipoproteincholesterol levels in the pre-eclampsia group were significantlyhigher during the second trimester compared to the first trimesterin the same groups, and serum very low density lipoproteincholesterol levels in both groups were significantly higher duringthe second trimester compared to the first trimester (p = 0.016 andp < 0.001, respectively). Conclusions: Serum total cholesterol,low density lipoprotein cholesterol, very low density lipoproteincholesterol and triglyceride levels raised from the first to the secondtrimester of pregnancy. Serum high density lipoprotein cholesterollevels increased only in pregnant women with pre-eclampsia duringthe second trimester of pregnancy. Pregnant women with preeclampsiahad higher serum high density lipoprotein cholesteroland very low density lipoprotein cholesterol levels compared withpregnant women with no pre-eclampsia. |
