P-13 EVALUATION OF UNDIAGNOSED ALCOHOLIC LIVER DISEASE IN PATIENTS WITH METABOLIC DYSFUNCTION-ASSOCIATED FATTY LIVER DISEASE USING THE ANI SCORE

Autor: Carlos Alventosa Mateu, Mercedes Latorre Sánchez, Inmaculada Castelló Miralles, Benjamín Climent Díaz, Juan José Urquijo Ponce, Moisés Diago Madrid
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Annals of Hepatology, Vol 29, Iss , Pp 101627- (2024)
Druh dokumentu: article
ISSN: 1665-2681
DOI: 10.1016/j.aohep.2024.101627
Popis: Conflict of interest: No Introduction and Objectives: The 2024 EASL-EASD-EASO guidelines on Steatotic Liver Disease emphasize the distinction between Metabolic Dysfunction-Associated Steatotic Liver Disease (MAFLD) and the subcategories with significant alcohol consumption: Alcoholic Liver Disease (ALD) and Metabolic ALD (MetALD). To this aim, a systematic record of alcohol consumption and/or validated biomarkers is recommended.To evaluate the likelihood of associated but unrecognized alcohol-related liver disease (MetALD/ALD) in patients managed for MAFLD. Patients / Materials and Methods: A single-center retrospective study that analyzes the probability of MetALD/ALD using the ALD/NAFLD (ANI) score in patients diagnosed with MAFLD during May/June 2024. MAFLD was defined by the presence of hepatic steatosis with alcohol intake 0 (indicative of a probability >50%). Sociodemographic variables, alcohol consumption, and hepatic fibrosis were recorded and compared between the ANI>0 and ANI0), with half of these (9/18) showing a probability >90%. Alcohol intake (10-20/30 g/day) was significantly higher in the ANI>0 group, consisting solely of males. Hepatic fibrosis was more pronounced in this group (7.6±3.6 vs 5.9±1.7) but did not reach statistical significance. Conclusions: The significant prevalence of unrecognized MetALD/ALD by ANI score suggests that alcohol consumption may be underreported in the ANI>0 group. Therefore, the inclusion of the ANI score as a biomarker for accurate differentiation MAFLD from MetALD/ALD appears to be beneficial.
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