| Autor: |
Chandana Choudhury Barua, Lipika Buragohain, Hooriyah Rizavi, Samir Bikash Gogoi, Farida Rahman, Bandi Siva, K. Mounika, K. Suresh Babu, Debesh Chandra Pathak, Arabinda Phukan |
| Jazyk: |
angličtina |
| Rok vydání: |
2020 |
| Předmět: |
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| Zdroj: |
Journal of Ayurveda and Integrative Medicine, Vol 11, Iss 4, Pp 464-470 (2020) |
| Druh dokumentu: |
article |
| ISSN: |
0975-9476 |
| DOI: |
10.1016/j.jaim.2018.02.140 |
| Popis: |
Background: Entada phaseoloides is a well-known medicinal plant traditionally used in Ayurvedic medicine for centuries. Objective: To evaluate the anti-stress activity of seeds of E. phaseoloides in endoplasmic reticulum stress during chronic restrain stress in mice, based on our preliminary screening. Materials and Methods: Mice (n = 6/group) were restrained daily for 6 h in 50 ml polystyrene tubes for 28 days. Methanolic extract of E. phaseoloides (MEEP) (100 and 200 mg/kg, p.o.) and standard drug, imipramine (10 mg/kg i.p.) were administered daily 45 min prior to restrain from day 22–28. Then, forced swim test (FST) was performed to assess despair behavior. Lipid peroxidation (LPO) and antioxidant enzymes Reduced glutathione (GSH), Superoxide dismutase (SOD) were measured in the hippocampus of mice. 78 kDa Glucose-regulated Protein, 94 kDa Glucose-regulated Protein, C/EBP homologous protein, Caspase-12 expression were quantified by Real Time PCR. Results: MEEP significantly reduced the immobility time in FST (P |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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