Antigenic structure of the human coronavirus OC43 spike reveals exposed and occluded neutralizing epitopes

Autor: Chunyan Wang, Emma L. Hesketh, Tatiana M. Shamorkina, Wentao Li, Peter J. Franken, Dubravka Drabek, Rien van Haperen, Sarah Townend, Frank J. M. van Kuppeveld, Frank Grosveld, Neil A. Ranson, Joost Snijder, Raoul J. de Groot, Daniel L. Hurdiss, Berend-Jan Bosch
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-022-30658-0
Popis: Human coronavirus OC43 causes respiratory disease and is maintained in the human population through recurring infections. Here, by extensive structural analyses, the authors provide insights into the binding sites and breadth of neutralizing antibodies against this endemic coronavirus.
Databáze: Directory of Open Access Journals