| Autor: |
Zhiguo Zhu, Xujun Xuan, Xinkun Wang, Miaomiao Wang, Chunyang Meng, Zhonghai Li |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
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| Zdroj: |
FEBS Open Bio, Vol 13, Iss 10, Pp 1967-1985 (2023) |
| Druh dokumentu: |
article |
| ISSN: |
2211-5463 |
| DOI: |
10.1002/2211-5463.13688 |
| Popis: |
Testicular germ cell tumors (TGCT) are the most common type of testicular cancer, comprising 90–95% of cases and representing the most prevalent solid malignancy in young adult men. Immune infiltrates play important regulatory roles in tumors, but their role in TGCT remains unclear. Molecular subtyping is a promising way to provide precisely personalized treatment and avoid unnecessary toxicities. This study investigated immune infiltrates, key biomarkers, and immune subtyping of TGCT. In GSE3218, 24 differentially expressed immune genes (immDEGs) were identified. A new risk signature consisting of six immDEGs was developed using these genes. Individuals in the high‐risk group had poor overall survival (OS; hazard ratio of 4.61 and P‐value |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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