| Autor: |
Daniel J. van Wamelen, Anna Sauerbier, Valentina Leta, Carmen Rodriguez-Blazquez, Cristian Falup-Pecurariu, Mayela Rodriguez‐Violante, Alexandra Rizos, Y. Tsuboi, Vinod Metta, Roongroj Bhidayasiri, Kalyan Bhattacharya, Rupam Borgohain, L. K. Prashanth, Raymond Rosales, Simon Lewis, Victor Fung, Madhuri Behari, Vinay Goyal, Asha Kishore, Santiago Perez Lloret, Pablo Martinez-Martin, K. Ray Chaudhuri |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021) |
| Druh dokumentu: |
article |
| ISSN: |
2045-2322 |
| DOI: |
10.1038/s41598-021-88651-4 |
| Popis: |
Abstract Growing evidence suggests that non-motor symptoms (NMS) in Parkinson’s disease (PD) have differential progression patterns that have a different natural history from motor progression and may be geographically influenced. We conducted a cross-sectional analysis of 1607 PD patients of whom 1327 were from Europe, 208 from the Americas, and 72 from Asia. The primary objective was to assess baseline non-motor burden, defined by Non-Motor Symptoms Scale (NMSS) total scores. Other aims included identifying the factors predicting quality of life, differences in non-motor burden between drug-naïve and non-drug-naïve treated patients, and non-motor phenotypes across different geographical locations. Mean age was 65.9 ± 10.8 years, mean disease duration 6.3 ± 5.6 years, median Hoehn and Yahr stage was 2 (2–3), and 64.2% were male. In this cohort, mean NMSS scores were 46.7 ± 37.2. Differences in non-motor burden and patterns differed significantly between drug-naïve participants, those with a disease duration of less than five years, and those with a duration of five years or over (p ≤ 0.018). Significant differences were observed in geographical distribution (NMSS Europe: 46.4 ± 36.3; Americas: 55.3 ± 42.8; Asia: 26.6 ± 25.1; p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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