Effects of valproic acid on wound healing of the abdominal wall musculoaponeurotic layer: an experimental study in rats
| Autor: | RACHEL BIONDO SIMÕES, MARIA DE LOURDES PESSOLE BIONDO SIMÕES, SÉRGIO OSSAMU IOSHII, ROGÉRIO RIBEIRO ROBES, MOACIR OLIVEIRA DALL’ANTONIA, MATHEUS PRINCE GOEHR, PEDRO JUAN FURTADO NEVES |
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| Jazyk: | English<br />Spanish; Castilian<br />Portuguese |
| Rok vydání: | 2024 |
| Předmět: | |
| Zdroj: | Revista do Colégio Brasileiro de Cirurgiões, Vol 51 (2024) |
| Druh dokumentu: | article |
| ISSN: | 1809-4546 0100-6991 |
| DOI: | 10.1590/0100-6991e-20243676-en |
| Popis: | ABSTRACT Introduction: valproic acid (VPA), an epigenetic drug, has potential for the treatment of neoplasms. Its effects on the healing of the peritoneal-musculo-aponeurotic plane (PMA) of the abdominal wall are studied. Method: sixty Wistar rats were allocated into two groups: experimental (VPA) and control (0.9% sodium chloride), treated daily, starting three days before the intervention and until euthanasia. Under anesthesia, a median laparotomy was performed and repaired with two synthetic layers. Assessments took place 3, 7 and 14 days after surgery. The integrity of the wounds, the quality of the inflammatory reaction, the intensity of the leukocyte infiltrate, collagen synthesis, the intensity of angiogenesis and the presence of myofibroblasts were studied. Results: there was dehiscence of the PMA plane in 11 of the 30 animals (p=0.001) in the experimental group. There was no difference in the quality and intensity of the inflammatory reaction. Immunohistochemistry revealed, in the experimental group, less collagen I (p3=0.003, p7=0.013 and p14=0.001) and more collagen III (p3=0.003, p7=0.013 and p14= 0.001). Collagen evaluated by Sirus Supra Red F3BA showed, in the experimental group, less collagen at all three times (p |
| Databáze: | Directory of Open Access Journals |
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