| Autor: |
Young-Sick Kim, Hyun-Kyung Chang, Jin-Woo Lee, Yun-Hee Sung, Sung-Eun Kim, Mal-Soon Shin, Jae-Woo Yi, Je-Hoon Park, Hong Kim, Chang-Ju Kim |
| Jazyk: |
angličtina |
| Rok vydání: |
2009 |
| Předmět: |
|
| Zdroj: |
Journal of Pharmacological Sciences, Vol 109, Iss 1, Pp 144-147 (2009) |
| Druh dokumentu: |
article |
| ISSN: |
1347-8613 |
| DOI: |
10.1254/jphs.08067SC |
| Popis: |
Gabapentin was developed as an anticonvulsant, but has also been used to alleviate hyperalgesia in neuropathic pain. In this study, the protective effect of gabapentin against N-methyl-D-aspartate (NMDA)-induced excitotoxicity in rat hippocampal CA1 neurons was investigated. Pre-treatment with gabapentin reduced the degree of neuronal damage induced by NMDA exposure in cultured hippocampal slices. Patch-clamp studies revealed that gabapentin significantly inhibited the NMDA receptor–activated ion current in dissociated hippocampal CA1 neurons, resulting in suppression of glutamate-induced neuronal injury. These results show that gabapentin may exert protective effects against glutamate-induced neuronal injury at least in part by inhibiting the NMDA receptor–activated ion current. Keywords:: gabapentin, N-methyl-D-aspartate, neuroprotection |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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