GTSE1: A potential prognostic and diagnostic biomarker in various tumors including lung adenocarcinoma

Autor: Guanqiang Yan, Guosheng Li, Xiang Gao, Jun Liu, Yue Li, Jingxiao Li, Huafu Zhou
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: The Clinical Respiratory Journal, Vol 18, Iss 5, Pp n/a-n/a (2024)
Druh dokumentu: article
ISSN: 1752-699X
1752-6981
DOI: 10.1111/crj.13757
Popis: Abstract Objective This research was aimed to comprehensively investigate the expression levels, diagnostic and prognostic implications, and the relationship with immune infiltration of G2 and S phase‐expressed‐1 (GTSE1) across 33 tumor types, including lung adenocarcinoma (LUAD), through gene expression profiling. Methods GTSE1 mRNA expression data together with clinical information were acquired from Xena database of The Cancer Genome Atlas (TCGA), ArrayExpress, and Gene Expression Omnibus (GEO) database for this study. The Wilcoxon rank‐sum test was used to detect differences in GTSE1 expression between groups. The ability of GTSE1 to accurately predict cancer status was evaluated by calculating the area under the curve (AUC) value for the receiver operating characteristic curve. Additionally, we investigated the predictive value of GTSE1 in individuals diagnosed with neoplasms using univariate Cox regression analysis as well as Kaplan–Meier curves. Furthermore, the correlation between GTSE1 expression and levels of immune infiltration was assessed by utilizing the Tumor Immune Estimate Resource (TIMER) database to calculate the Spearman rank correlation coefficient. Finally, the pan‐cancer analysis findings were validated by examining the association between GTSE1 expression and prognosis among patients with LUAD. Results GTSE1 exhibited significantly increased expression levels in a wide range of tumor tissues in contrast with normal tissues (p
Databáze: Directory of Open Access Journals
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje