Nasal Provocation Test with Cat and Dog Extracts: Results according to Molecular Components

Autor: Andres Sánchez, Ricardo Cardona, Marlon Munera, Victor Calvo, Manuela Tejada-Giraldo, Jorge Sánchez
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Pulmonary Medicine, Vol 2020 (2020)
Druh dokumentu: article
ISSN: 2090-1836
2090-1844
DOI: 10.1155/2020/6365314
Popis: Background. IgE sensitization (atopy) to pets is commonly evaluated using pet dander extracts. However, the diagnosis by components seems to be more adequate to evaluate the clinical relevance (allergy) of sIgE sensitization. Objective. To study the association between IgE sensitization to pet allergen components and clinical symptoms. Methodology. Dander extracts and sIgE levels to pet components (Can f 1, Can f 2, Can f 3, Can f 5, Fel d 1, Fel 2, and Fel 4) were measured in a rhinitis group (n=101) and a control group (n=68). Nasal provocation tests with pet extract were done in patients with atopy to pets. Results. Dog (34.6% vs. 23.5%) and cat dander (26.7% vs. 8.8%, p=0.05) IgE sensitization was frequent among rhinitis and no-rhinitis subjects, and it was similar to dog (29.7% vs. 20.5%) and cat (18.8% vs. 8.8%) components. Polysensitization for dog (3.1, 95% CI: 1.5 to 6.1, p
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