| Autor: |
Seyed MohammadReza Hashemian, Navid Shafigh, Golnaz Afzal, Hamidreza Jamaati, Payam Tabarsi, Majid Marjani, Majid Malekmohammad, Seyed Mehdi Mortazavi, Batoul Khoundabi, Davood Mansouri, Afshin Moniri, Abbas Hajifathali, Elham Roshandel, Esmaeil Mortaz, Ian M Adcock |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
Pulmonology, Vol 27, Iss 6, Pp 486-492 (2021) |
| Druh dokumentu: |
article |
| ISSN: |
2531-0437 |
| DOI: |
10.1016/j.pulmoe.2020.10.017 |
| Popis: |
Background: In December 2019, pneumonia associated with a novel coronavirus (COVID-19) was reported in Wuhan, China. Acute respiratory distress syndrome (ARDS) is the most frequently observed complication in COVID-19 patients with high mortality rates. Objective of study: To observe the clinical effect of plasmapheresis on excessive inflammatory reaction and immune features in patients with severe COVID-19 at risk of ARDS. Materials and methods: In this single-center study, we included 15 confirmed cases of COVID-19 at Masih Daneshvari Hospital, in March 2020 in Tehran, Iran. COVID-19 cases were confirmed by RT-PCR and CT imaging according to WHO guidelines. Plasmapheresis was performed to alleviate cytokine-induced ARDS. The improvement in oxygen delivery (PaO2/FiO2), total number of T cells, liver enzymes, acute reaction proteins, TNF-α and IL-6 levels were evaluated. Results: Inflammatory cytokine levels (TNF-α, IL-6), and acute phase reaction proteins including ferritin and CRP were high before plasmapheresis. After plasmapheresis, the levels of PaO2/FiO2, acute phase reactants, inflammatory mediators, liver enzymes and bilirubin were significantly reduced within a week (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
|
