| Autor: |
Yuya Machi, Jina Yoshida, Hideo Kojima |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
|
| Zdroj: |
Results in Chemistry, Vol 8, Iss , Pp 101564- (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2211-7156 |
| DOI: |
10.1016/j.rechem.2024.101564 |
| Popis: |
We investigated the asymmetric reduction of β-keto esters using aquatic plants as whole-cell biocatalysts under darkness and illumination by fluorescent light. The (S)- β-hydroxy esters were obtained with high enantiomeric excess (ee) values. Regardless of the light conditions, the amount of (R)- β-hydroxy ester produced did not change significantly as the substrate concentration increased, whereas the yield of (S)- β-hydroxy ester increased substantially. Moreover, increasing the quantity of plants resulted in a significant increase in the production of (S)- β-hydroxy ester and a slight increase in the production of (R)- β-hydroxy ester, reducing the ee value. The reaction proceeded more efficiently for substrates bearing bulkier ester moieties, of which the tert-butyl ester gave the best results. Ultimately, we concluded that aquatic plants can be used as whole-cell biocatalysts for preparing optically active β-hydroxy esters. This result represents a new use of aquatic plants and contributes to the achievement of carbon neutrality. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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