Changes in urinary potassium excretion in patients with chronic kidney disease

Autor: Yuichiro Ueda, Susumu Ookawara, Kiyonori Ito, Haruhisa Miyazawa, Yoshio Kaku, Taro Hoshino, Kaoru Tabei, Yoshiyuki Morishita
Jazyk: English<br />Korean
Rok vydání: 2016
Předmět:
Zdroj: Kidney Research and Clinical Practice, Vol 35, Iss 2, Pp 78-83 (2016)
Druh dokumentu: article
ISSN: 2211-9132
DOI: 10.1016/j.krcp.2016.02.001
Popis: Background: Hyperkalemia is one of the more serious complications of chronic kidney disease (CKD), and the cause of potassium retention is a reduction in urinary potassium excretion. However, few studies have examined the extent of the decrease of urinary potassium excretion in detail with respect to decreased renal function. Methods: Nine hundred eighty-nine patients with CKD (CKD stages G1 and G2 combined: 135; G3a: 107; G3b: 170; G4: 289; and G5: 288) were evaluated retrospectively. Values for urinary potassium excretion were compared between CKD stages, and the associations between urinary potassium excretion and clinical parameters, including diabetes mellitus status and use of renin–angiotensin–aldosterone system inhibitors, were analyzed using a multivariable linear regression analysis. Results: Urinary potassium excretion gradually decreased with worsening of CKD (G5: 24.8 ± 0.8 mEq/d, P
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